Inclusion complexes between sildenafil citrate and cyclodextrins enhance drug solubility
نویسندگان
چکیده
منابع مشابه
Melarsoprol-cyclodextrins inclusion complexes.
Melarsoprol, a water-insoluble drug, is mainly used in the treatment of trypanosomiasis and has demonstrated an in vitro activity on myeloid and lymphoid leukemia derived cell lines. It is marketed as a very poorly tolerated non-aqueous solution (Arsobal). The aim of our work was to develop melarsoprol-cyclodextrin complexes in order to improve the tolerability and the bioavailability of melars...
متن کاملFixed Drug Eruption Caused by Sildenafil Citrate
Vol. 29, No. 2, 2017 247 Received August 24, 2015, Revised April 7, 2016, Accepted for publication April 10, 2016 Corresponding author: Kui Young Park, Department of Dermatology, Chung-Ang University Hospital, Chung-Ang University College of Medicine, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, Korea. Tel: 82-2-6299-1525, Fax: 82-2-823-1049, E-mail: [email protected] This is an Open Access arti...
متن کاملInclusion complexes of trihexyphenidyl with natural and modified cyclodextrins
The solubility of trihexyphenidyl (Thp) was improved by its combination with β-cyclodextrin (β-CD) and modified β-CDs. The solubility of Thp was found to be increased in the presence of β-CD, hydroxypropyl-β-cyclodextrin (HP-β-CD), methyl-β-cyclodextrin (Me-β-CD) and sulfobutylether-β-cyclodextrin (SBE-β-CD). In particular, the solubility of Thp in conjunction with SBE-β-CD was increased by a f...
متن کاملInclusion complexes of poorly water-soluble drugs with glucosyl-cyclodextrins.
glucosyl-ƒ¿-CD (G-ƒ¿-CD), 6-O-ƒ¿-D-glucosyl-ƒÀ-CD (G-ƒÀ-CD), and 6A,6D-di-O-ƒ¿-D-glucosyl-ƒÀ-CD (2G-ƒÀ-CD) with slightly soluble or insoluble drugs in aqueous solution and in the solid state was studied by the solubility method, ultraviolet spectroscopy, and differential scanning calorimetry. These glucosyl-CDs were capable of forming inclusion complexes with compounds which can form complexes ...
متن کاملSolubility Enhancement of Raloxifene Using Inclusion Complexes and Cogrinding Method
The objective of the present work was to enhance the solubility and dissolution of practically water-insoluble drug raloxifene HCl (RLX), for the same two approaches that were used. In the first approach, drug was kneaded with hydroxypropyl-β-cyclodextrin (HPβCD), and in the second one drug was cogrinded with modified guar gum (MGG). The drug-cyclodextrin complex and drug-MGG cogrind mixtures w...
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ژورنال
عنوان ژورنال: Asian Journal of Pharmaceutical Sciences
سال: 2016
ISSN: 1818-0876
DOI: 10.1016/j.ajps.2015.11.105